- High insulin levels in people who are obese
- A family history of acanthosis nigricans
- A cancerous tumor (rarely)
Velvety-looking, dark areas on:
- Back of the neck
- Skin biopsy
- Blood tests
- Imaging tests such as X-rays or endoscopy to rule out other causes
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National Organization for Rare Diseases http://www.rarediseases.org/
American Academy of Dermatology http://www.aad.org/for-the-public/home
Health Canada http://www.hc-sc.gc.ca
Acanthosis nigricans. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed . Updated December 10, 2010. Accessed November 19, 2012.
Clark N, Stulberg DL, Tovey D. Common hyperpigmentation disorders in adults: part II. Melanoma, seborrheic keratoses, acanthosis nigricans, melasma, diabetic dermopathy, tinea versicolor, and postinflammatory hyperpigmentation. Am Fam Physician. 2003 Nov 15;68(10). Available at: http://www.aafp.org/afp/20031115/1963.html . Accessed November 19, 2012.
Goff DC, Katz AS, Feldman SR. Acanthosis nigricans in obese patients: presentations and implications for prevention of atherosclerotis vascular disease. Dermatology Online Journal . 2000;5(1). Available at: http://dermatology.cdlib.org/DOJvol6num1/original/acanthosis/katz.html . Accessed November 19, 2012.
10/15/2010 DynaMed's Systematic Literature Surveillance http://www.ebscohost.com/dynamed/what.php : Kong AS, Williams RL, Smith M, et al. Acanthosis nigricans and diabetes risk factors: prevalence in young persons seen in southwestern US primary care practices. Ann Fam Med. 2007;5(3):202-208. Kong AS, Williams RL, Rhyne R, et al. Acanthosis Nigricans: high prevalence and association with diabetes in a practice-based research network consortium—a PRImary care Multi-Ethnic network (PRIME Net) study. J Am Board Fam Med. 2010;23(4):476-485.
- Reviewer: Brian Randall, MD
- Review Date: 03/2013 -
- Update Date: 00/31/2013 -